abstract：:NSUN5, a gene encodes a cytosine-5 RNA methyltransferase, is rarely mentioned in cancers. Our study is the first one to evaluate the role of NSUN5 in the progression of colorectal cancer. Data from TCGA was used to show the different expression of NSUN5 between CRC tumor tissues and adjacent normal ones. The NSUN5 exp...

journal_title：American journal of translational research

authors： Jiang Z,Li S,Han MJ,Hu GM,Cheng P

更新日期：2020-07-15 00:00:00

abstract：OBJECTIVE:To explore the utility of dual-energy spectral computed tomography (CT) in the differential diagnosis of focal organizing pneumonia (FOP) and solitary bronchioloalveolar carcinoma (S-BAC). MATERIALS AND METHODS:The institutional review board approved this study and waived the requirement for informed consent...

journal_title：American journal of translational research

authors： Zhang G,Cao Y,Zhang J,Zhao Z,Zhang W,Huang L,Zhang Z,Zhou J

更新日期：2020-07-15 00:00:00

abstract：:We report the case of a 29-year-old female with a 1.1 cm × 1.1 cm solitary nodule adjacent to the pleura in the upper lobe of the right lung that was diagnosed as Mycobacterium chelonae using electromagnetic navigation bronchoscopy combined with next generation sequencing. This diagnostics technology shows great promi...

journal_title：American journal of translational research

authors： Li Y,Zang Y,Wang Y,Jin F,Liu W

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:Mesenchymal stem cell (MSC)-based bone tissue engineering is a promising treatment option for maxillary sinus augmentation. Rapid vascularization is necessary to enhance the osteoinductive efficacy and prevent necrosis of the tissue-engineered bone. This study investigated whether the co-autotransplantation ...

journal_title：American journal of translational research

authors： Li Q,Yu T,Wang F,Liu X,Wang Z

更新日期：2020-06-15 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, and it has a poor prognosis. Emerging evidence shows that circular RNAs (circRNAs) may act as good therapeutic targets for cancers due to their abundance and stability. However, their regulatory role in CRC needs further investigation. This study r...

journal_title：American journal of translational research

authors： Wu HB,Huang SS,Lu CG,Tian SD,Chen M

更新日期：2020-06-15 00:00:00

abstract：:Spinal cord injury (SCI) is a severe traumatic disease of the central nervous system characterized by high incidence and disability rate. We aimed to investigate the therapeutic potential of Ezetimibe (Eze) in SCI and identify the underlying mechanisms. Acute SCI rat model was established by using the modified weight-...

journal_title：American journal of translational research

authors： Chen G,Li J,Wang Z,Liu W

更新日期：2020-06-15 00:00:00

abstract：:The purpose of the current study was to investigate the differences in knee kinematics and kinetics in patients with semilunar lateral meniscus (SLM) and discoid lateral meniscus (DLM) injuries before and after arthroscopic partial meniscectomy during level walking. Fifteen healthy volunteers (control group), thirteen...

journal_title：American journal of translational research

authors： Li Y,Wu Y,Zeng Y,Gu D

更新日期：2020-06-15 00:00:00

abstract：:The random pattern skin flap has been an important procedure in plastic and reconstructive surgery to cover various challenging defects. However, distal flap necrosis is problematic. Crocin is a natural carotenoid compound, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-i...

journal_title：American journal of translational research

authors： Cai L,Xie L,Dong Q

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer, but the CDH3 expression levels...

journal_title：American journal of translational research

authors： Zhou Y,Chi Y,Bhandari A,Xia E,Thakur PC,Qu J,Wang O,Zhang X

更新日期：2020-06-15 00:00:00

abstract：:Circular RNAs (circRNAs), a new star noncoding RNA (ncRNA), show stability, conservation, abundance, and tissue and stage specificity. They act as key regulators of biological processes. They target the mRNAs of many other different genes or signaling pathways, and closely link associated genes into regulatory network...

journal_title：American journal of translational research

authors： Zhou DN,Ye CS,Deng YF

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:We previously constructed AdEasy system for rapid generation of recombinant adenovirus expressing coding genes. However, it is unclear if AdEasy system could be used for exogenously expression of long noncoding RNAs (lncRNAs). Here we investigated how to overexpress lncRNA H19 with AdEasy system and identifi...

journal_title：American journal of translational research

authors： Liao J,Xiao H,Dai G,He T,Huang W

更新日期：2020-05-15 00:00:00

abstract：:Glioma-associated oncogene homolog 1 (GLI1), an oncogenic molecule in non-small cell lung cancer (NSCLC), promotes the growth of NSCLC by enhancing lung cancer stem cells (LCSCs). However, the mechanism responsible remains unknown. FOXP3 is known to maintain LCSCs. The aim of this study was to explore whether GLI1 enh...

journal_title：American journal of translational research

authors： Qi H,Li W,Zhang J,Chen J,Peng J,Liu Y,Yang S,Du J,Long X,Ng CS,Li MY,Chen GG

更新日期：2020-05-15 00:00:00

abstract：:This study aimed to verify the effects of calpain on coxsackievirus B3 (CVB3)-induced myocarditis and to further explore the underlying mechanisms. Transgenic mice overexpressing calpastatin, the endogenous calpain inhibitor, were introduced in the present study. The murine model of viral myocarditis (VMC) was establi...

journal_title：American journal of translational research

authors： Yu Y,Shi H,Yu Y,Liu M,Li M,Liu X,Wang Y,Chen R

更新日期：2020-05-15 00:00:00

abstract：:The quantity and function of osteoblasts require continuous osteogenic differentiation of bone marrow mesenchymal stem cells. Recent evidence suggests that microRNAs (miRNAs) act as important post-transcriptional regulators in a wide range of biological processes, including osteoblastic differentiation. Quercetin has ...

journal_title：American journal of translational research

authors： Zhang Q,Chang B,Zheng G,Du S,Li X

更新日期：2020-05-15 00:00:00

abstract：:HOE-642 has been shown to provide significant protection in a variety of models of cerebral and myocardial ischemia/reperfusion injury. In this study, we examined the impact of HOE-642, a selective Na+/H+ exchanger 1 inhibitor, with or without hypothermia on neuronal and neuronal mitochondrial function during resuscit...

journal_title：American journal of translational research

authors： Wei L,Zhang P,Hu Y,Zhao W,Liu X,Wang X,Han F

更新日期：2020-05-15 00:00:00

abstract：:Ellagic acid (EA), a polyphenolic compound from pomegranate fruit extracts, has been reported to possess anti-proliferation, pro-apoptosis, and anti-invasion effects on many cancers. However, its effect on melanoma is yet to be clarified. In the present study, we investigated the anti-cancer effects of EA on melanoma ...

journal_title：American journal of translational research

authors： Wang F,Chen J,Xiang D,Lian X,Wu C,Quan J

更新日期：2020-05-15 00:00:00

abstract：:Liver cancer is ranked as the 5th major type of cancer and is responsible for significant number of human deaths across the world. Recent investigations have shown microRNAs (miRs) to be involved in diverse cellular processes. Additionally, they have been shown to exhibit therapeutic implications in treatment of diffe...

journal_title：American journal of translational research

authors： Sun W,Li W,Chen J,Teng Y,Ding X

更新日期：2020-04-15 00:00:00

abstract：:This study aimed to explore the effects of long non-coding RNA (lncRNA) expression on rheumatoid arthritis (RA). LncRNA expression profiles were obtained from the synovial tissues of five RA patients and five age-/gender-matched controls by RNA-Seq. Six candidate lncRNAs were then chosen and their levels in synovial f...

journal_title：American journal of translational research

authors： Piao X,Zhou J,Hu J

更新日期：2020-04-15 00:00:00

abstract：:Accumulating evidence indicates that competing endogenous RNA networks play a critical role in cirrhosis progression. However, their biological role and regulatory mechanisms in liver sinusoidal endothelial cells (LSECs) have not been explored. Here, we exposed LSECs to starvation and lipopolysaccharide (LPS) treatmen...

journal_title：American journal of translational research

authors： Zhang R,Huang XQ,Jiang YY,Li N,Wang J,Chen SY

更新日期：2020-03-15 00:00:00

abstract：:MicroRNAs (miRNAs) are small regulatory non-coding RNAs that have been reported to play an important role in the tumorigenesis of many cancers. In addition, miRNAs might serve as new promising biomarkers for diagnosis and prognosis and as effective therapeutic targets for patients with such malignancies. Accordingly, ...

journal_title：American journal of translational research

authors： Zhang L,Zhang Y,Wang S,Tao L,Pang L,Fu R,Fu Y,Liang W,Li F,Jia W

更新日期：2020-03-15 00:00:00

abstract：BACKGROUND:This study tested the long-term effect of extracorporeal shock wave (ECSW) therapy on ameliorating radiotherapy-induced chronic cystitis (CC) in rat. METHODS AND RESULTS:Adult-female SD rats (n = 24) were equally categorized into group 1 (normal control), group 2 (CC induced by radiotherapy with 450 cGy twi...

journal_title：American journal of translational research

authors： Chen YT,Yang CC,Sung PH,Lin KC,Chiang JY,Huang CR,Huang KH,Chuang FC,Chu YC,Huang EY,Yip HK

更新日期：2020-03-15 00:00:00

abstract：:The microRNA-29 family, which contains mir-29a, mir-29b, and mir-29c, can promote or resist the development of several types of tumors. However, its role in rhabdomyosarcoma (RMS) has not been determined. In this work, we detected the expression of mir-29a/b/c in RMS. Results showed that the tissues and cell lines in ...

journal_title：American journal of translational research

authors： Wang Y,Zhang L,Pang Y,Song L,Shang H,Li Z,Liu Q,Zhang Y,Wang X,Li Q,Zhang Q,Liu C,Li F

更新日期：2020-03-15 00:00:00

abstract：:Immunotherapy using antibodies blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway has achieved great success in preclinical models and the clinical treatment of esophageal squamous cell carcinoma (ESCC). The c-Myc proto-oncogene helps prevent immune cells from attacking tumor ce...

journal_title：American journal of translational research

authors： Liang MQ,Yu FQ,Chen C

更新日期：2020-02-15 00:00:00

abstract：:The clinical efficacy of PD-1/PD-L1 monoclonal antibodies (mAbs) in triple-negative breast cancer (TNBC) is unsatisfactory. Immunotherapy combined with chemotherapy shows good therapeutic potential. Preclinical and clinical studies have shown that metronomic chemotherapy may stimulate anticancer immune responses. We a...

journal_title：American journal of translational research

authors： Chen Q,Xia R,Zheng W,Zhang L,Li P,Sun X,Shi J

更新日期：2020-02-15 00:00:00

abstract：:Cullin-5 (CUL5), a scaffold protein in active cullin-RING ubiquitin ligase (CRL) complexes, is a member of the cullin family of proteins. The CUL5-type ubiquitin ligase can target multiple proteins involved in ubiquitination and proteasome degradation. CUL5 plays positive roles in regulating cell growth, proliferation...

journal_title：American journal of translational research

authors： Gao F,Fan Y,Zhou B,Guo W,Jiang X,Shi J,Ren C

更新日期：2020-02-15 00:00:00

abstract：:Targeted oncolytic adenoviruses can selectively replicate in cancer cells; combined with traditional chemotherapy drugs, this approach is expected to become an important treatment method for overcoming the current bottleneck of osteosarcoma treatment. Here, we investigate the effect of oncolytic adenovirus Ad11 combin...

journal_title：American journal of translational research

authors： Zhang B,Zhang Y,Li R,Li J,Lu X,Zhang Y

更新日期：2020-01-15 00:00:00

abstract：:Skeletal muscle injuries can cause significant change in the ultrastructure and the metabolism of the skeletal muscle cells. Observation of the ultrastructure and measurements of the metabolism biomarkers such as total superoxide dismutase (T-SOD), malondialdehyde (MDA), and creatine kinase (CK) can be used to evaluat...

journal_title：American journal of translational research

authors： Guan H,Zhao L,Liu H,Xie D,Liu Y,Zhang G,Mason DC,Zhang S,Li Y,Zhang H

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:To provide novel insight into the development of new therapeutic strategies to combat breast cancer, differentiation-inducing activity of clinically achievable concentrations of arsenite (AsIII) and tetrandrine (Tetra) was investigated in breast cancer cell lines MDA-MB-231 and MCF-7. METHODS:Differentiatio...

journal_title：American journal of translational research

authors： Yu B,Yuan B,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Pei X,Takagi N

更新日期：2019-12-15 00:00:00

abstract：BACKGROUND:Infection can induce and aggravate chronic kidney disease (CKD), and the chemotaxis of Th22 cells may aggravate CKD. However, the mechanism underlying group A Streptococcus (GAS) infections in CKD through the chemotaxis of Th22 cells remains unknown. METHODS:The experiment was divided into a normal control ...

journal_title：American journal of translational research

authors： Xiao C,Xiao P,Li X,Huang G,Li H,Chen Y

更新日期：2019-12-15 00:00:00

abstract：:The goal of this study was to assess the role of high-mobility group box 1 (HMGB1)-induced endothelial cell (EC) pyroptosis in systemic inflammatory response syndrome (SIRS) following radiofrequency (RF) ablation of hepatic hemangiomas. We enrolled 76 patients with hepatic hemangioma who underwent RF ablation. Serum c...

journal_title：American journal of translational research

authors： Yang M,Yang X,Wang S,Xu L,Ke S,Ding X,Sun W,Gao J

更新日期：2019-12-15 00:00:00

abstract：:Increasing evidence demonstrate that dysregulated microRNAs (miRNAs) are involved in carcinogenesis and tumor progression in papillary thyroid cancer (PTC). However, the specific miR-761 in cancer remains largely unknown. In this study, we reported for the first that miR-761 expression was down-regulated in PTC tissue...

journal_title：American journal of translational research

authors： Yin X,Zhang J,Li C,Zhang Z,Jin T,Song L,Zhang R,Wang W,Tao Y,Wang X

更新日期：2019-11-15 00:00:00

abstract：:Programmed cell death ligand 1 (PD-L1) is a key suppressor of the cytotoxic immune response. In colorectal carcinoma (CRC), PD-L1 expression results in immune escape and poor prognosis. Extensive researches suggested that metformin had a potential efficacy of enhancing anti-tumor immune response in different types of ...

journal_title：American journal of translational research

authors： Zhang JJ,Zhang QS,Li ZQ,Zhou JW,Du J

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory intestinal disease, and its morbidity is rising worldwide. Previous study indicated that astragaloside II (AS II), a monomeric compound, was used to treat bowel disease. However, the effects of AS II on UC remains unclear. Thus, this study aimed to investigat...

journal_title：American journal of translational research

authors： Qiao C,Wan J,Zhang L,Luo B,Liu P,Di A,Gao H,Sun X,Zhao G

更新日期：2019-11-15 00:00:00

abstract：:LncRNAs have been shown to invovled in the development of various cancers. However, the function and potential mechanism of PTCSC3 in cervical carcinoma progression remains unknown. In this reference, we showed that PTCSC3 expression was downregulated in 4 cervical carcinoma cell lines (Caski, Siha, Hela and C4-1) com...

journal_title：American journal of translational research

authors： Zhang M,Song Y,Yu L

更新日期：2019-11-15 00:00:00

abstract：:Glioma is an aggressive nervous system tumor with poor prognosis. Although the therapeutic strategies to overcome glioma have been improved largely recent years, the potential mechanism of its carcinogenesis remains largely unclear. The present study aimed to investigate the role of long non-coding RNA HOMEOBOX A11 an...

journal_title：American journal of translational research

authors： Jiang J,Wang X,Gao G,Liu X,Chang H,Xiong R,Lu J,Sun Z

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) X-inactive specific transcript (XIST) has identified to involve into the tumor cell angiogenesis. However, whether XIST contributes to Human Brain Microvascular Endothelial Cells (HBMEC) angiogenesis as well as potential mechanisms are largely unclear. METHODS:The expression o...

journal_title：American journal of translational research

authors： Hu C,Bai X,Liu C,Hu Z

更新日期：2019-10-15 00:00:00

abstract：:Radiation-induced heart disease (RIHD) is a common sequelae of thoracic irradiation. Currently, there is no effective prevention and treatment strategy. Oxidative stress is associated with the development of RIHD. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) has been defined as the multipotent prope...

journal_title：American journal of translational research

authors： Li H,Cao L,Yi PQ,Xu C,Su J,Chen PZ,Li M,Chen JY

更新日期：2019-10-15 00:00:00

abstract：:Alopecia areata is characterized by the loss of hair on the scalp and elsewhere on the body. It affects approximately 2% of the general population. It is believed to be an autoimmune disease. However, its pathogenesis remains incompletely understood. Recent studies have revealed a substantial link between vitamin D an...

journal_title：American journal of translational research

authors： Lin X,Meng X,Song Z

更新日期：2019-09-15 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM), a leading cause of osteoporosis, remains a contraindication for bone implant therapy. Although associated with side effects when systemically administered, biphosphonates (BPs) play a positive role in diabetic osteoporosis treatment. We hypothesized that local BP therapy would prevent ...

journal_title：American journal of translational research

authors： Ding X,Yang L,Hu Y,Yu J,Tang Y,Luo D,Zheng L

更新日期：2019-09-15 00:00:00

abstract：BACKGROUND:Sorafenib is an oral multi-kinase inhibitor that inhibits hepatocellular carcinoma (HCC) via the Ras/Raf/MAPK pathway. However, sorafenib loses effectiveness because most tumors acquire drug resistance over time. As the PI3K/AKT/mTOR signaling pathway is also activated abnormally in HCC, we evaluated the eff...

journal_title：American journal of translational research

authors： Li A,Zhang R,Zhang Y,Liu X,Wang R,Liu J,Liu X,Xie Y,Cao W,Xu R,Ma Y,Cai W,Wu B,Cai S,Tang X

更新日期：2019-09-15 00:00:00